Don't Miss our Product Theater Presentation
Monday, July 17 at 1:30 PM
The Mastermind of the Alzheimer’s Blood Test
Presented by Inge Verberk, Ph.D.
Postdoctoral Researcher at Amsterdam UMC, VUmc, Department of Clinical Chemistry, Neurochemistry Laboratory
ABSTRACT
Blood based biomarkers for detection of neurological disorders such as Alzheimer’s disease (AD) have significantly advanced in clinical validation status in recent years and are beginning to see use in clinical practice. There is a growing view that multiple biomarkers are needed to help sort out the complexities of AD, co-pathologies, and non-AD dementias. Phospho-tau (pTau), neurofilament light chain (NfL), glial acidic fibrillary protein, amyloid beta 40, and amyloid beta 42 are the blood-based biomarkers that have received the most attention, and combinations of these biomarkers have been shown to be more accurate for AD detection than individual biomarkers alone. NfL, while not specific for AD, can be informative for non-AD pathologies in the context of the other biomarkers, particularly pTau. In this talk, we will discuss work aimed at optimizing a multi-biomarker approach to aid differential diagnosis of AD from other dementias with a simple blood test.
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