Porcine cross reactivity in human Simoa assays; TBI Study | App Note


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The Quanterix Simoa HD-1/ HD-X Analyzer offers an unprecedented ability to measure low abundant brain injury proteins  in human circulation. A Yorkshire swine experimental traumatic brain injury (TBI) model that is used to study novel  europrotective therapies for TBI provides an excellent opportunity for studying the kinetics of blood biomarkers of  brain injury. This study explored the potential porcine cross-reactivity in human assays for neuron-specific enoloase  NSE), Neurofilament light (NF-light™), glial fibrillary acidic protein (GFAP), and cardiac Troponin I (cTnI).