Discovery Fueled by Ultrasensitivity

Get Ultrasensitive Biomarker Measurements with Simoa

From discovery to diagnostics, Quanterix’s ultrasensitive biomarker detection technology is fueling breakthroughs made possible through its unparalleled sensitivity and flexibility. Simoa® technology has delivered the gold standard for earlier biomarker detection in blood, serum, or plasma, with the ability to quantify proteins that are far lower than the Level of Quantification (LoQ). Our industry-leading precision instruments, digital immunoassay technology, and CLIA-certified Accelerator laboratory support research that advances disease understanding and management in neurology, oncology, immunology, cardiology, and infectious disease.  

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Simoa Technology

Measure Biomarkers at Lower Levels Than Ever Before

Our Simoa Bead Technology allows researchers to detect biomarkers at femtogram levels with results in record time. How it works: 

  1. Paramagnetic particles coupled with antibodies that bind to specific targets are added to the sample.
  2. Detection antibodies capable of generating fluorescent product are added, resulting in an immunocomplex consisting of the bead-bound protein, and detection antibody.
  3. The sample is loaded into arrays in the Simoa disc where each microwell is sized to admit one bead and the presence of a bound protein is indicated by a fluorescent signal from the bead. Results are digital- meaning each bead either contains an analyte, along with detection antibody, or it does not.
  4. Results can be viewed and analyzed on the board or exported for further analysis to commonly used software packages or LIMS systems.

Quanterix offers two instruments that utilize bead technology. The Simoa HD-X™ Analyzer offers a fully automated Simoa bead-based immunoassay platform designed to multiplex up to 4 biomarkers in a single assay with unrivaled sensitivity. The SR-X™ detection system is our compact and affordable system offering simple workflows with minimal user intervention for running bead-based assays.  


With the ability to measure up to 10-plex biomarkers, our Simoa Planar Array Technology offers a simple and flexible platform with unique capabilities to support needs in immuno-oncology and other research areas. How it works:

  1. 96-well plates that are spotted with the target analyte(s) of interest.
  2. Researchers add diluted samples and standards to each well and the plates create a unique surface chemistry and “vortex” effect.
  3. Biotinylated detection antibodies are added to form the other half of the immunocomplex “sandwich”.
  4. Between additional shake cycles, high sensitivity HRP enzyme-conjugated streptavidin is added.
  5. Finally, a chemiluminescent substrate is added just prior to imaging with an ultra-sensitive CCD camera to measure the signal intensity produced by each spot.

Planar technology can be accessed via the  SP-X Imaging and Analysis System™,  a complete benchtop system that offers true multiplex detection at both acute and baseline levels in serum and plasma. Its unique capabilities are designed specifically to address many of today’s unmet needs in immuno-oncology and other research areas. 

Complete the form to the left to learn more about our immunoassay platforms, variety of assays, and services like our Accelerator Laboratory. 

Our Current Portfolio

Choose The Right Platform For Your Research.

Simoa® Accelerator Laboratory 

Utilize our CLIA-certified laboratory as a cost-effective, outsourced solution for your custom biomarker and biopharmaceutical research, assay development, and clinical sample testing needs.

HD-X™ Automated Immunoassay Analyzer

The Simoa HD-X AnalyzerTM  is the latest model of the fully automated Simoa bead-based immunoassay platform. The HD-X delivers increased productivity, user flexibility, unparalleled sensitivity and best in class assay performance. 

Simoa® Homebrew Assays

Quanterix offers the flexibility of multiplex homebrew assay development to minimize required sample volume; providing full kits that include all reagents and training required to develop these custom homebrew assays.